Publications

Sulic, A.-M., Das Roy, R., Papagno, V., Qiang, L., Saikkonen, S., Jernvall, J., Thesleff, I. & Mikkola, M. Transcriptomic landscape of early hair follicle and epidermal development. Cell Reports (2023). Link

Christensen, M. M., Hallikas, O., Das Roy, R., Väänänen, V., Stenberg, O. E., Häkkinen, T. J., François, J-C., Asher R. J., Klein O. D., Holzenberger, M., & Jernvall, J. The developmental basis for scaling of mammalian tooth size. PNAS (2023). Link

Väänänen, V., Christensen, M. M., Suhonen, H., & Jernvall, J. Gene expression detection in developing mouse tissue using in situ hybridization and µCT imaging. PNAS (2023). Link

Löytynoja, A., Rastas, P., Valtonen, M., Kammonen, J., Holm, L., Olsen, M. T., Jernvall, J. & Auvinen, P. Fragmented habitat compensates for the adverse effects of genetic bottleneck. Current Biology (2023). Link

Sundell, T., Kammonen, J. I., Mustaoja, E., Biard, V., Kunnasranta, M., Niemi, M., Nykänen, M., Nyman, T., Palo, J. U., Valtonen, M., Paulin, L., Jernvall, J. & Auvinen, P. Genomic evidence uncovers inbreeding and supports translocations in rescuing the genetic diversity of a landlocked seal population. (2023)Conservation Genetics Link

Väänänen, V. K., Christensen, M. M., Suhonen, H. & Jernvall, J. GECT-Gene Expression Detection in Developing Tissue Using Micro CT Imaging. bioRxiv, 2022.11.16.515587 Link

Christensen, M. M., Hallikas, O., Das Roy, R. , Väänänen, V. K., Stenberg, O. E., Häkkinen, T. J., Francois, J-C., Asher, R. J., Klein, O. D., Holzenberger, M. & Jernvall, J. The developmental basis for scaling of mammalian tooth size. bioRxiv, 2022.12.03.518730. Link

Cano‐Fernández, H. & Jernvall, J. Finite element analysis of crenulated and non‐crenulated hominid molars: A functional hypothesis explaining the adaptive significance of molar crenulation. American Journal of Biological Anthropology (2022). Link

Newham, E., Gill, P. G., Benton, M. J., Brewer, P., Gostling, N. J., Haberthür, D., Jernvall, J. Tuomas Kankanpää, Kallonen, A., Navarro, C., Pacureanu, A., Richards, K., Robson Brown, K., Schneider, P., Suhonen, H., Tafforeau, P., Williams, K., Zeller-Plumhoff, P. & Corfe I. J. Reply to: Revisiting life history and morphological proxies for early mammaliaform metabolic rates. Nature communications 13 , 5564: (2022). Link

Das Roy, R., Hallikas, O., Christensen, M. M., Renvoisé, E. & Jernvall, J. Chromosomal neighbourhoods allow identification of organ specific changes in gene expression PLoS Computational Biology 17 (2021). e1008947 Link

Hallikas, O., Das Roy, R., Christensen, M. M., Renvoisé, E., Sulic, A.-M. & Jernvall J. – System-level analyses of keystone genes required for mammalian tooth development. J. Exp. Zool. Part B: Mol. Dev. Evol. 1–11: (2021). doi: 10.1002/jez.b.23009 Link

Morita , W. , Morimoto , N. & & Jernvall J. – Mapping molar shapes on signaling pathways. PLOS Computational Biology11 (2020). doi: 10.10.1371/journal.pcbi.1008436 Link

Newham E., Gill, P. G., Brewer, P., Benton, M. J., Fernandez, V., Gostling, N. J., Haberthür, H. P., Jernvall, J. Kankaanpää, Kallonen A., Navarro C., Pacureanu, A., Richards, K., Brown, K. R., Schneider, P., Suhonen, H., Tafforeau, P., Williams, K. A., Zeller-Plumhoff, B. & Corfe I. J. – Reptile-like physiology in Early Jurassic stem-mammals. Nature Communications 11: 5121 (2020). Link

Laakkonen J. & Jernvall, J. – Muscles of mastication and the temporo-mandibular joint of the Saimaa (Phoca hispida saimensis) and Baltic (Phoca hispida botnica) ringed Seal. Annales Zoologici Fennici 57: 21–29 (2020). PDF

Häkkinen, T. J., Sova, S. S., Corfe, I. J., Tjäderhane, L., Hannukainen, A. & Jernvall J. – Modeling enamel matrix secretion in mammalian teeth PLOS Computational Biology5(2019). doi:10.1371/journal.pcbi.1007058 Link GitHub Cosmos Physicsworld

Savriama, Y., Valtonen, M., Kammonen, J., Rastas, P., Smolander, O.-P., Lyyski, A., Häkkinen, T. J., Corfe, I. J., Gerber, S., Salazar-Ciudad, I., Paulin, L., Holm, L., Löytynoja, A., Auvinen, P. & Jernvall J. – Bracketing phenotypic limits of mammalian hybridisation. R Soc Open Sci 5 : (2018) doi.org/10.1098/rsos.180903. Link

Marin-Riera, M., Moustakas-Verho, J., Savriama, Y., Jernvall J. & Salazar-Ciudad, I. – Differential tissue growth and cell adhesion alone drive early tooth morphogenesis: An ex vivo and in silico study. PLoS Computational Biology 14: e1005981 (2018). https://doi.org/10.1371/journal.pcbi.1005981 Link

Sova, S. S., Tjäderhane, L., Heikkilä, P. A & Jernvall J. – A microCT study of three-dimensional patterns of biomineralization in pig molars. Frontiers in Physiology 9: 71(2018). doi: 10.3389/fphys.2018.00071 Link

Aivelo, T., Medlar, A., Löytynoja, A., Laakkonen, & Jernvall J. – Metabarcoding gastrointestinal nematodes in sympatric endemic and non-endemic species in Ranomafana National Park, Madagascar. International Journal of Primatology 39: 49–64 (2018). doi: 10.1007/s10764-017-0010-x Link

Eronen, J. T., Zohdy, S., Evans, A. R., Tecot, S. R., Wright, P. C. & Jernvall, J. – Feeding ecology and morphology make a bamboo specialist vulnerable to climate change. Current Biology 27: 3384–3389 (2017). Link

Prochazkova, M. Häkkinen, T., Prochazka, J., Spoutil, F., Jheon, A. H., Ahn, Y., Krumlauf, F., Jernvall J. & Klein, O. D. – FGF signaling refines Wnt gradients to regulate patterning of taste papillae. Development: dev.148080 (2017). Link

Renvoisé, E., Kavanagh, K. D., Lazzari, D., Häkkinen, T., Rice, R., Pantalacci, S., Salazar-Ciudad, I. & Jernvall J. – Mechanical constraint from growing jaw facilitates mammalian dental diversity. Proceedings of the National Academy of Sciences 35: 3537–3547 (2017). Link

Zohdy, S., Bisanzio, D., Tecot, S., Wright, P. C., & Jernvall, J. – Aggression and hormones are associated with heterogeneity in parasitism and parasite dynamics in the brown mouse lemur. Animal Behaviour 132: 109–119 (2017). Link

Aivelo, T. J. E., Laakkonen, J. T. & Jernvall, J. – Population- and individual-level dynamics of the intestinal microbiota of a small primate. Applied and Environmental Microbiology 299: 3537–3547 (2016). Link

Evans, A. E., Daly, E. S., Catlett, K. K., Paul, K. S., King, S. J., Skinner, M. M., Nesse, H. P., Hublin, J-J., Townsend, G. C., Schwartz, G. T. & Jernvall, J. – A simple rule governs the evolution and development of hominin tooth size. Nature 530: 477–480 (2016). Link

Laakkonen J. & Jernvall, J. – Macroscopic Anatomy of the Saimaa Ringed Seal (Phoca hispida saimensis) Lower Respiratory Tract. Anatomical Record 82: 538–543 (2016). PDF

Aivelo, T., Medlar, A., Löytynoja, A., Laakkonen, J. & Jernvall J. – Tracking year-to-year changes in intestinal nematode communities of rufous mouse lemurs (Microcebus rufus). Parasitology 142: 1095–1107 (2015). Link

Tapaltsyan, V., Eronen, J. T., Lawing, A. M., Sharir, A., Janis, C., Jernvall, J. & Klein, O. D. – Continuously Growing Rodent Molars Result from a Predictable Quantitative Evolutionary Change over 50 Million Years. Cell Reports 11: 673–680 (2015). Link

Vesterinen, H. M., Corfe, I., Sinkkonen, V., Iivanainen, A., Jernvall, J. & Laakkonen J. Teat morphology characterization with 3D imaging. Anatomical Record. 298: 1359–1366 (2015). Link

Zohdy S., Gerber B., Tecot S., Blanco M. B., Wright P. C. & Jernvall J. Teeth, Sex, and Testosterone: Aging in the world’s smallest primate. PLOS ONE. (2014) Online

Horvath, J. E., Ramachandran, G. L., Fedrigo, O., Nielsen, W. J., Babbitt, C. C., St. Clair, E. M., Pfefferle, L. W., Jernvall, J., Wray, G. A. & Wall, C. E. – Genetic comparisons yield insight into the evolution of enamel thickness during human evolution. Journal of Human Evolution 73: 75–87 (2014). PDF

Harjunmaa, E., Seidel, K, Häkkinen, T., Renvoisé, E., Corfe, I. J., Kallonen, A., Zhang, Z-Q., Evans, A. R., Mikkola, M. L., Salazar-Ciudad, I. Klein, O. D.& Jernvall, J. – Replaying evolutionary transitions from the dental fossil record. Nature 512: 44–48 (2014). Link See News and Views (Luo 2014)

Laakkonen, J., Kankaanpää, T., Corfe, I. J., Jernvall, J., Soveri, T., Keovichit, K. & Hugot, J-P. – Gastrointestinal and dental morphology of herbivorous mammals: where does the Laotian rock rat fit? In :Annales Zoologici Fennici 51: 153—161 (2014). Online

Gomes Rodrigues, H., Renaud, S., Charles, C., Le Poul, Y., Solé, F., Aguilar, J.-P., Michaux, J., Tafforeau, P., Headon, D., Jernvall, J. & Viriot, L. – Roles of dental development and adaptation in rodent evolution. Nature Communications 4: 2504 doi: 10.1038/ncomms3504 (2013). Link

Salazar-Ciudad, I. & Jernvall, J., – The causality horizon and the developmental bases of morphological evolution. Biological Theory 8: 286 – 292 (2013). Link

Jernvall J. & Thesleff I. – Tooth shape formation and tooth renewal: evolving with the same signals. Development 139: 3487 – 3497 (2012). PDF

Häärä O., Harjunmaa E., Lindfors P. H., Huh S-H., Fliniaux I., Åberg T., Jernvall J., Ornitz D., Mikkola M. L. & Thesleff I. – Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling. Development 139: 3189 – 3199 (2012). PDF

Zohdy S., Kemp A.D., Lance A.D., Wright P.C. & Jernvall J. – Mapping the social network: tracking lice in a wild primate (Microcebus rufus) population to infer social contacts and vector potential. BMC Ecology 12: doi:10.1186/1472-6785-12-4(2012). Online ScienceShot Scientific American

Wilson G.P., Evans A.R., Corfe I.J., Smiths P.D., Fortelius M. & Jernvall J. – Adaptive radiation of multituberculate mammals before the extinction of dinosaurs. Nature 483: 457– 460 (2012). Link Talk nerdy to me

Harjunmaa E., Kallonen A., Voutilainen M., Hämäläinen K., Mikkola M. L. & Jernvall J. – On the difficulty of increasing dental complexity. Nature 483: 324 – 327 (2012). Link

Boyer, D. M., Lipman, Y., Clair, E. S., Puenta, J., Patel, B. A., Funkhouser, T., Jernvall, J. & Daubechies, I. – Algorithms to automatically quantify the geometric similarity of anatomical surfaces. Proceedings of the National Academy of Sciences, USA 108: 18221–18226 (2011). PDF

King, S., J., Boyer, D. M., Tecot, Strait, S. G., S. Zohdy, S., Blanco, M. B., Wright, P. C. & Jernvall, J. – Lemur habitat and dental senescence in Ranomafana National Park, Madagascar. American Journal of Physical Anthropology 145: 228–237 (2011).

Bunn, J. M., Boyer, D. M., Lipman, Y., St. Clair, E., Jernvall, J. & Daubechies, I. – Comparing Dirichlet normal surface energy of tooth crowns, a new technique of molar shape quantification for dietary inference, with previous methods in isolation and in combination. American Journal of Physical Anthropology 145: 247–261 (2011).

Munne, P. M., Felszeghy, S., Jussila, M., Suomalainen, M., Thesleff, I., Jernvall, J. – Splitting placodes: effects of bone morphogenetic protein and Activin on the patterning and identity of mouse incisors. Evolution and Development Jul-Aug;12(4): 383-92 (2010). PDF

Boyer, D. M., Evans, A. R. & Jernvall, J. – Evidence of dietary differentiation among late Paleocene-early Eocene plesiadapids (Mammalia, Primates). American Journal of Physical Anthropology 142: 194–210 (2010). PDF

Skinner, M. M., Evans, A., Smith, T., Jernvall, J., Tafforeau, P., Kupczik, K., Olejniczak, A. J., Rosas, A., Radovcic, J., Thakeray, J. F., Toussaint, M., & Hublin, J.-J. – Brief Communication: Contributions of enamel-dentine junction shape and enamel deposition to primate molar crown complexity. American Journal of Physical Anthropology 142: 157–163 (2010). PDF

Salazar-Ciudad, I. & Jernvall, J. – A computasalaasasational model of teeth and the developmental origins of morphological variation. Nature 464: 583–586 (2010). Link

Eronen J. T., Evans A. R., Fortelius M., & Jernvall J. – The impact of regional climate on the evolution of mammals: A case study using fossil horses. Evolution 64: 398-408 (2010). PDF

Munne P. M., Mark Tummers, Järvinen E., Thesleff I. & Jernvall, J. – Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction. Development 136: 393–402 (2009). doi:10.1242/dev.025064 Online

Jernvall, J., Gilbert, C. C. & Wright, P. C. (2008). Peculiar tooth homologies of the greater bamboo lemur (Prolemur = Hapalemur simus): When is a paracone not a paracone? J. G. Fleagle & C. C. Gilbert (eds), In: Elwyn Simons: A Search for Origins, Springer, New York, pp. 335–342. PDF

Järvinen, E., Välimäki, K., Pummila, M., Thesleff, I. & Jernvall, J. (2008). The taming of the shrew milk teeth. Evolution and Development 10: 477–486. PDF

Wright, P. C., King, S. J., Baden, A. & Jernvall, J. (2008). Aging in wild female lemurs: Sustained fertility with increased infant mortality. Primate Reproductive Aging, S. Atsalis, S. W. Margulis & P. R. Hof (eds), In: Interdisciplinary Topics in Gerontology Vol. 36, Karger Press, Basel, pp. 17–28.

Plyusnin, I., Evans, A.R., Karme, A., Gionis, A., & Jernvall, J. (2008). Automated 3D Phenotype Analysis Using Data Mining. PLoS ONE 3(3): e1742.doi:10.1371/journal.pone.0001742 PDF Online

Kavanagh, K.D., Evans, A.R., & Jernvall, J. (2007). Predicting evolutionary patterns of mammalian teeth from development. Nature 449: 427–432. See News and Views (Polly 2007).

Evans, A.R., Wilson, G.P., Fortelius, M., & Jernvall, J. (2007). High-level similarity of dentitions in carnivorans and rodents. Nature 445: 78–81. PDF

Järvinen, E., Salazar-Ciudad, I., Birchmeier, W., Taketo, M.M., Jernvall, J. & Thesleff, I. (2006). Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling. Proceedings of the National Academy of Sciences, USA 103: 18627–18632. PDF

Klein, O.D., Minowada, G., Peterkova, R., Kangas, A., Yu, B.D., Lesot, H., Peterka, M., Jernvall, J. & Martin, G.R. (2006). Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Developmental Cell 11: 181–190. PDF

Fortelius, M., Gionis, A., Jernvall, J. & Mannila, H. (2006). Spectral ordering and biochronology of European fossil mammals. Paleobiology 32: 206–214. PDF

King, S.J., Arrigo-Nelson, S.J., Pochron, S.T., Semprebon, G.M., Godfrey, L.R., Wright, P.C. & Jernvall, J. (2005). Dental senescence in a long-lived primate links infant survival to rainfall. Proceedings of the National Academy of Sciences, USA 102: 16579–16583. PDF

Salazar-Ciudad, I., & Jernvall, J. (2005). Graduality and innovation in the evolution of complex phenotypes: insights from development. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 304B: 619–631. PDF

Kassai, Y., Munne, P., Hotta, Y., Penttilä, E., Kavanagh, K., Ohbayashi, N., Takada, S., Thesleff, I., Jernvall, J. & Itoh, N. (2005). Regulation of mammalian tooth cusp patterning by ectodin. Science 309: 2067–2070. PDF

Jernvall, J., & Fortelius, M. (2004). Maintenance of trophic structure in fossil mammal communities: site occupancy and taxon resilience. American Naturalist 164: 614–624. PDF

Salazar-Ciudad, I., & Jernvall, J. (2004). How different types of pattern formation mechanisms affect the evolution of form and development. Evolution and Development 6: 6–16. PDF

Kangas, A.T., Evans, A.R., Thesleff, I., & Jernvall, J. (2004). Nonindependence of mammalian dental characters. Nature 432: 211–214. PDF PUBMED

Salazar-Ciudad, I., Jernvall, J., & Newman, S.A. (2003). Mechanisms of pattern formation in development and evolution. Development 130: 2027–2037. PDF

Jernvall, J., Wright, P.C., Ravoavy, F.L., & Simons, E.L. (2003). Report on findings of subfossils at Ampoza and Ampanihy in southwestern Madagascar. Lemur News 8: 21–23. PDF

Fortelius, M., Eronen, J., Jernvall, J., Liu, L., Pushkina, D., Rinne, J., Tesakov, A., Vislobokova, I., Zhang, Z., & Zhou, L. (2002). Fossil mammals resolve regional patterns of Eurasian climate change over 20 million years. Evolutionary Ecology Research 4: 1005–1016. PDF

Jernvall, J., & Fortelius, M. (2002). Common mammals drive the evolutionary increase of hypsodonty in the Neogene. Nature 417: 538–540. PDF

Salazar-Ciudad, I., & Jernvall, J. (2002). A gene network model accounting for development and evolution of mammalian teeth. Proceedings of the National Academy of Sciences, USA. 99: 8116–8120. Program files PDF

Jernvall, J. (2000). Linking development with generation of novelty in mammalian teeth. Proceedings of the National Academy of Sciences, USA. 97: 2641–2645. PDF

Jernvall, J., Hunter, J.P., & Fortelius, M. (2000). Trends in the evolution of molar crown types in ungulate mammals: evidence from the Northern Hemisphere. In: Development, Function and Evolution of Teeth, M. Teaford, M.M. Smith & M. Ferguson (eds), Cambridge University Press, pp. 269–281.

Jernvall, J., & Jung, H.-S. (2000). Genotype, phenotype and developmental biology of molar tooth characters. Yearbook of Physical Anthropology 43: 171–190. PDF

Jernvall, J., Keränen, S.V.E., & Thesleff, I. (2000). Evolutionary modification of development in mammalian teeth: Quantifying gene expression patterns and topography. Proceedings of the National Academy of Sciences, USA. 97: 14444–14448. PDF

Jernvall, J., & Thesleff, I. (2000). Return of lost structure in the developmental control of tooth shape. In: Development, Function and Evolution of Teeth, M. Teaford, M.M. Smith & M. Ferguson (eds), Cambridge University Press, pp. 13–21.

Jernvall, J., & Thesleff, I. (2000). Reiterative signaling and patterning during mammalian tooth morphogenesis. Mechanisms of Development 92: 19–29. PDF

Jernvall, J., & Selänne, L. (1999). Laser confocal microscopy and geographic information systems in the study of dental morphology. Palaeontologia Electronica 2(1): 18 p., 905KB. Online PDF

Keränen, S.V.E., Kettunen, P., Åberg, T., Thesleff, I., & Jernvall, J. (1999). Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema region. Development, Genes and Evolution 209: 495–506. PDF

Pispa, J., Jung, H.-S., Jernvall, J., Kettunen, P., Mustonen, T., Tabata, M.J., Kere, J., & Thesleff, I. (1999). Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF. Developmental Biology 216: 521–534. PDF

Wright, P.C., & Jernvall, J. (1999). The future of primate communities: a reflection of the present? In: Primate communities, J.G. Fleagle, C. Janson & K. Reed (eds), Cambridge University Press, pp. 295–309.

Jernvall, J., & Wright, P.C. (1998). Diversity components of impending primate extinctions. Proceedings of the National Academy of Sciences, USA. 95: 11279–11283. PDF

Jernvall, J., Åberg, T., Kettunen, P., Keränen, S., & Thesleff, I. (1998). The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development 125: 161–169. PDF

Keränen, S.V.E., Åberg, T., Kettunen, P., Thesleff, I., & Jernvall, J. (1998). Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents. Development, Genes, and Evolution 208: 477–486. PDF

Jernvall, J., Hunter, J.P., & Fortelius, M. (1996). Molar tooth diversity, disparity, and ecology in Cenozoic ungulate radiations. Science 274: 1489–1492. PDF

Vaahtokari, A., Åberg, T., Jernvall, J., Keränen, S., & Thesleff, I. (1996). The enamel knot is a signaling center in the developing mouse tooth. Mechanisms of Development 54: 39–43. PDF

Jernvall, J. (1995). Mammalian molar cusp patterns: Developmental mechanisms of diversity. Acta Zoologica Fennica 198: 1–61.

Hunter, J.P., & Jernvall, J. (1995). The hypocone is a key innovation in mammalian evolution. Proceedings of the National Academy of Sciences, USA. 92: 10718–10722. PDF

Jernvall, J., Kettunen, P., Karavanova, I., Martin, L.B., & Thesleff, I. (1994). Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene. International Journal of Developmental Biology 38: 463–469.